Original Articles

Impaired Bronchoprotection Is Not Induced by Increased Smooth Muscle Mass in Chronic Treatment In Vivo with Formoterol in Asthmatic Mouse Model

Issue:

Vol 63, Issue 6: Oct (2014)

DOI:

10.7727/wimjopen.2014.177

Pages:

641–6

Synopsis:

Compelling evidence proves that bronchial smooth muscle mass significantly increases in asthmatics, and chronic formoterol administration induces impaired bronchoprotection. No significant difference was detected in increased smooth muscle mass, implying that some other molecular mechanisms might be involved.

ABSTRACT

Received:

24 Jul, 2014

Accepted:

11 Aug, 2014

PDF Attachment:

luo_et_al-impaired_bronchoprotection_and_increased_smooth_muscle_mass.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 16 Jan, 2015

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Insulin Control of Blood Glucose and GLUT4 Expression in the Skeletal Muscle of Septic Rats

Issue:

Vol 64, Issue 2: March (2015)

DOI:

10.7727/wimj.2013.181

Pages:

62–70

Synopsis:

Insulin increased the expression of GLUT4 mRNA and GLUT4 in the skeletal muscle of septic rats. Blood glucose concentration of 8–10 mmol/L results in more glucose utilization than 6–8 mmol/L in the skeletal muscle of septic rats during insulin therapy.

ABSTRACT

Background: Insulin resistance is common in septic patients. The level at which the serum glucose should be maintained using insulin infusions for optimal utilization by skeletal muscles is not yet established.

Received:

28 May, 2013

Accepted:

03 Jul, 2013

PDF Attachment:

wimjmar2015_62_70.pdf

Journal Sections:

Keywords:

glucose transporter 4 (GLUT4)

Journal Authors:

e-Published: 16 Dec, 2014

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Underestimated Prevalence of Chronic Heart Failure among Elderly Residing in Care Homes in Aruba

Issue:

Vol 63, Issue 6: Oct (2014)

DOI:

10.7727/wimj.2013.277

Pages:

610–5

Synopsis:

The prevalence of chronic heart failure (CHF) among the elderly in care homes in Aruba is high (31%) and underestimated. B-type natriuretic peptide testing adds value to the usual diagnostic work-up for CHF in these elderly.

ABSTRACT

Objective: Diagnosing chronic heart failure (CHF) is important, since subsequent treatments by medication and cardiac intervention improve quality of life. However, accurate CHF diagnosis in the elderly residing in care homes (residents) is hampered by suboptimal diagnostic tools, co-morbidity and physician’s unawareness of CHF. We sought to estimate the CHF prevalence among Aruban residents.

Received:

09 Oct, 2013

Accepted:

23 Jan, 2014

PDF Attachment:

stoutjesdijk_et_al-prevalence_of_heart_failure_in_care_homes_for_the_elderly.pdf

Journal Sections:

Original Articles

Keywords:

prevalence

elderly

B-type natriuretic peptide

chronic heart failure

Journal Authors:

e-Published: 04 Nov, 2014

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Study of Different Involutive Changes in Bone Mineral Density Measured in Ward’s Triangle and Trabecular Volume Measured in Iliac Crest in Relation to Age

Issue:

Vol 64, Issue 2: March (2015)

DOI:

10.7727/wimj.2014.046

Pages:

108–12

Synopsis:

Involutional changes occur in bone mineral density during the process of ageing. Body mass index has a great influence on bone mineral density.

ABSTRACT

Background: The ageing process causes changes in the bone structure, in bone mineral density, and musculoskeletal disorders.

Aims: The purpose of this study is to evaluate and compare involutive changes in bone structure that occur in relation to age in men and women through the study of bone mineral density at the Ward’s triangle and trabecular volume.

Received:

17 Feb, 2014

Accepted:

20 Feb, 2014

PDF Attachment:

wimjmar2015_108_112.pdf

Journal Sections:

Keywords:

bone histomorphometry

Journal Authors:

RF Castillo

RF Gallegos

e-Published: 21 Oct, 2014

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Comparison of Cerebral Oximeter and Pulse Oximeter Values in the First 72 Hours in Premature, Asphyctic and Healthy Newborns

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2014.033

Pages:

698–702

Synopsis:

Cerebral oximeter is a promising modality in bedside monitoring in neonatal intensive care units. It is complementary to pulse oximeter and may be used routinely in neonatal intensive care units.

^ABSTRACT

Aim: The monitoring of oxygenation is essential for providing patient safety and optimal results. We aimed to determine brain oxygen saturation values in healthy, asphyctic and premature newborns and to compare cerebral oximeter and pulse oximeter values in the first 72 hours of life in neonatal intensive care units.

Received:

04 Feb, 2014

Accepted:

02 Apr, 2014

PDF Attachment:

wimjdec2014_698_702.pdf

Journal Sections:

Original Articles

Keywords:

Neonatal Intensive Care Unit

Journal Authors:

e-Published: 03 Sep, 2014

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Systems for Paediatric Sepsis: A Global Survey

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2013.326

Pages:

703–10

Synopsis:

Even among centres with no significant resource constraints and advanced medical systems, significant deficits in sepsis care exist. Early recognition and management remain a key issue and may be addressed through improved triage, augmented support for referring centres and public awareness.

ABSTRACT

Objectives: To evaluate the resources available for early diagnosis and treatment of paediatric sepsis at hospitals in developing and developed countries.

Received:

09 Dec, 2013

Accepted:

21 Jan, 2014

PDF Attachment:

wimjdec2014_703_710.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 03 Sep, 2014

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Exploration of the Genetic Epidemiology of Asthma: A Review, with a Focus on Prevalence in Children and Adolescents in the Caribbean

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2014.115

Pages:

687–92

Synopsis:

The authors address and review the literature and findings regarding the epidemiology and genetic factors involved in the pathogenesis of asthma, with an included focus on the epidemiology and prevalence of this debilitating condition in the child and adolescent Caribbean population.

ABSTRACT

Received:

19 May, 2014

Revised:

05 Sep, 2014

Accepted:

05 Jun, 2014

PDF Attachment:

wimjdec2014_687_692.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 03 Sep, 2014

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3Ps-Pharmacist, Physician and Patient: Proposal for Joint Cooperation to Increase Adherence to Medication

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2013.222

Pages:

744–51

Synopsis:

Older people receive medications for chronic diseases and therefore adherence is an important health and economic concern. Enhancing communication between the physician, the pharmacist and the patient is key in boosting the patient's ability to follow a medication regimen and thus improve adherence to medication.

ABSTRACT

Objective: Older people receive medications for chronic diseases and therefore adherence is an important health and economic concern. The objective of the study is to determine relationships between pharmacist, patient and patient's family physician with special emphasis on the comparison of adherent and non-adherent patients.

Received:

13 Aug, 2013

Accepted:

28 Nov, 2013

PDF Attachment:

wimjdec2014_744_751.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 29 Aug, 2014

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The Incidence of Cardiac Lesions among Children with Down’s Syndrome in Jamaica - A Prospective Study

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2013.216

Pages:

693–7

Synopsis:

The incidence of Down's syndrome in Jamaica is similar to the reported international experience. The distribution of cardiac malformations is similar to other countries, except for the higher incidence of congenital heart disease and a higher incidence of combined lesions.

ABSTRACT

Objectives: This study aimed to define the incidence of Down’s syndrome and to describe the epidemiology of cardiac lesions in Jamaican children with Down’s syndrome.

Study Design: A prospective study was conducted on 53 infants during the period January 1, 2007 to December 31, 2007, at the Bustamante Hospital for Children, Kingston, Jamaica. A medical history, physical examination and echo Doppler was performed on each child.

Received:

28 Nov, 2013

Accepted:

11 Dec, 2013

PDF Attachment:

wimjdec2014_693_697.pdf

Journal Sections:

Original Articles

Keywords:

African decent

atrioventricular septal defect

congenital heart defect

Journal Authors:

C Scott

M Thame

e-Published: 26 Aug, 2014

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Cutaneous Malignant Melanoma in Jamaica, 1958 to 2007

Issue:

Vol 63, Issue 7: Dec (2014)

DOI:

10.7727/wimj.2013.265

Pages:

717–20

Synopsis:

In Jamaica, cutaneous malignant melanoma is commoner in females, but the incidence is low in both genders. The commonest anatomical site is the lower limb, particularly the foot. These findings are in keeping with those documented in other Black populations.

ABSTRACT

Objective: To document the epidemiology of cutaneous malignant melanoma (CMM) in Jamaica over the 50-year period, 1958–2007.

Received:

20 Sep, 2013

Accepted:

24 Feb, 2014

PDF Attachment:

wimjdec2014_717_720.pdf

Journal Sections:

Original Articles

Keywords:

Jamaica