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Original Articles

Elevated Ferric, Calcium and Magnesium Ions in the Brain Induce Protein Aggregation in Brain Mitochondria

Issue: 
Pages: 
122–7
Synopsis: 
This study evaluated the impact of elevated aluminum, ferric, calcium and magnesium ions on rabbit brain. Aluminum ion, but not the others, induced neurofibrillary degeneration within the midbrain and medulla. On the other hand, the other three ions caused aggregation of low molecular weight mitochondrial proteins.

 

ABSTRACT

Objective: Alzheimer’s disease and Parkinson’s disease are two of several neurodegenerative disorders that affect the elderly. Although their aetiology remains uncertain, studies suggest that elevated aluminium or other metal ions in the brain directly influence the development of the histological abnormalities normally associated with these diseases; other investigations suggest that metal-ioninduced-dysfunction of mitochondria might be a critical factor.

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e-Published: 19 Aug, 2013

Serum Lipids, Proteins and Electrolyte Profiles in Rats Following Total Body Irradiation

Issue: 
Pages: 
117–21
Synopsis: 
Cumulative total body irradiation caused subtle but significant changes in serum lipids, electrolytes and protein which may be due to non-specific stress reactions. As such, they are important markers in the diagnosis of radiation induced injury.


ABSTRACT

Objective: Serum lipid and electrolyte imbalances are common in critically ill patients undergoing radiation therapy. Although multiple disease states and medication may be responsible for the development of these disorders, the aim of this research is to sequentially document the effect of total body radiation on body function utilizing the sequential changes in the serum lipids, electrolytes and protein in rats.

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e-Published: 19 Aug, 2013

Wayward Effect of Polymorphism (TA)8 in the Promoter Region of UGT1A1 Gene in a Mexican Family

Issue: 
Pages: 
81–3
Synopsis: 
This is a report of the varied effects of Gilbert syndrome in a Mexican Mestizo family with a non-common (TA)8 repeat in this population.


ABSTRACT

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e-Published: 19 Aug, 2013

Epidemiology of Febrile Diseases in the Emergency Department of a Caribbean Island: The Curaçao Experience

Issue: 
Pages: 
76–80
Synopsis: 
This paper describes the aetiology and outcome of febrile patients at the emergency department of a general hospital in Curaçao. A high prevalence of bacterial infections and mortality were observed.


ABSTRACT

Objective: The aetiology of febrile diseases in tropical countries often remains poorly characterized. We aim to describe the aetiology and outcome of febrile illnesses at the Emergency Department (ED) in Curaçao.

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e-Published: 19 Aug, 2013

The Development of Anaesthetic Services in Jamaica

Issue: 
Pages: 
73–5
Synopsis: 
Formal training in the administration of anaesthesia was instituted on the recognition that dedicated physicians/ nurses offered a better morbidity/mortality profile to patients. Much progress has been made since the turn of the 20th century, in keeping with international standards.


“No nation, no race can face the future with confidence unless it knows what it is capable of. This is the function of history”. Charles Finch III.

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e-Published: 19 Aug, 2013

Role of Routine Chest Radiographs in the Evaluation of Patients with Stable Blunt Chest Trauma – A Prospective Analysis

Issue: 
Pages: 
64–72
Synopsis: 
The study sought to assess the test performance characteristics of clinical judgement in the evaluation of stable blunt chest trauma patients compared with chest radiography in the determination of significant intra-thoracic injury. The study revealed that physicians in the local emergency department may be over-utilizing chest radiographs for patients who had stable blunt chest trauma.


ABSTRACT

Objective: The study sought to assess the test performance characteristics of clinical judgement in the evaluation of stable blunt chest trauma patients compared with chest radiography (CXR) in the determination of significant intra-thoracic injury.

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e-Published: 19 Aug, 2013

An Assessment of Knowledge, Attitudes and Behaviour Regarding the Human Papillomavirus

Issue: 
Pages: 
58–63
Synopsis: 
The rate of cervical cancer as well as poor screening practices led to the study which was conducted on the St George’s University campus in Grenada. The results showed lack of knowledge about the relationship between human papillomavirus, cervical cancer and the associated risk factors.


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Objectives: This report is based on a study conducted in February 2010 that assessed the knowledge and attitudes toward cervical cancer and human papillomavirus (HPV) in Grenada which has a high incidence of cervical cancer.

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e-Published: 19 Aug, 2013

Fetal Central Nervous System Magnetic Resonance Imaging at the University Hospital of the West Indies, Jamaica

Issue: 
Pages: 
49–57
Synopsis: 
Fetal magnetic resonance imaging improved prenatal diagnosis, was a valuable contributor to patient counselling and led to changes in perinatal management.


ABSTRACT

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e-Published: 19 Aug, 2013

Drug Prescribing for Hypertension at Primary Healthcare Facilities in Trinidad

Issue: 
Pages: 
43–8
Synopsis: 
A cross-sectional survey at primary healthcare centres in Trinidad among hypertensive patients showed an attempt to follow prescribing guidelines. Angiotensin converting enzyme inhibitors were most commonly prescribed, but thiazide diuretics were underutilized.


ABSTRACT

Objective: To describe the drug prescribing pattern for hypertension at primary healthcare facilities throughout Trinidad.

Methods: A descriptive, cross-sectional survey was conducted at 22 primary healthcare facilities across Trinidad using a de novo, pilot-tested questionnaire during June to August 2006.

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e-Published: 19 Aug, 2013

Epidemiology of Neonatal Jaundice at the University Hospital of the West Indies

Issue: 
Pages: 
37–42
Synopsis: 
To reduce morbidity associated with neonatal jaundice at the University Hospital of the West Indies, there should be increased screening for G6PD deficiency and current systems in place for follow-up and monitoring of infants discharged from hospital prior to 72 hours must be expanded and strengthened.


ABSTRACT

Objective: To describe the epidemiology of neonatal jaundice at the University Hospital of the West Indies (UHWI).

Methods: A retrospective review of all neonates at the UHWI with clinically significant jaundice between January 1, 2006 and June 30, 2007 was performed. Demographic, clinical and laboratory data were collected. Descriptive analyses were performed.

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