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Original Articles

Pharmacological Evaluation of Marginally Designed New Profen Analogues

DOI: 
10.7727/wimj.2016.400
Synopsis: 
This study was conducted for the pharmacological evaluation of some novel analogues of naproxen, flurbiprofen and ibuprofen, well established COX inhibitors, with the goal of identifying a COX inhibitor(s) with optimized potency and efficacy. The synthesized and characterized analogues were tested for their acute toxicity, anti-inflammatory, analgesic and antipyretic activities based on the reported bioassay models. Molecular docking analysis was also performed to predict ligand: protein interactions. The synthesized analogues have highly significant pharmacological activities and have the potential to be further explored as new drug molecules. 

ABSTRACT

Received: 
26 Jan, 2016
Accepted: 
13 Feb, 2017
PDF Attachment: 
PDF icon halimi_et_al-marginally_designed_new_profen_analogues.pdf
Journal Sections: 
Original Articles
Keywords: 
anti-inflammatory
Analgesic
antipyretic
molecular docking
COX
Journal Authors: 
SMA Halimi
M Saeed
Safi-Ullah
KM Khan
e-Published: 02 Mar, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Antidiabetic Potential of Onosma hispidum Roots

DOI: 
10.7727/wimj.2016.436
Synopsis: 
In present study, antidiabetic potential of Onosma hispidum roots were assessed in diabetic animal models. O hispidum roots exhibited antihyperglycemic and antihyperlipidemic effects. In addition, histopathological investigation revealed pancreatic beta cells regeneration activity by plant roots.

ABSTRACT

Objective: To investigate the antihyperglycemic, antihyperlipidemic and pancreatic beta cells regeneration potentials of Onosma hispidum (ratanjot) root extracts in alloxan-induced diabetic rabbits.

Received: 
09 Aug, 2016
Accepted: 
13 Feb, 2017
PDF Attachment: 
PDF icon hussain_et_al-antidiabetic_potential_of_onosma_hispidum.pdf
Journal Sections: 
Original Articles
Keywords: 
diabetes mellitus
Alloxan
antihyperglycemia
Onosma hispidum
pancreatic beta cells
Journal Authors: 
F Hussain
A Ali
M Shahid
e-Published: 02 Mar, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

An Utstein-style Investigation into Prognoses Observed from the Condition of the Out-of-Hospital Cardiac Arrest Patients

DOI: 
10.7727/wimj.2016.449
Synopsis: 
At the time of 119 call, the subsequent survival rate is high particularly in conscious cases with chest pain / back pain / respiratory distress or in cases in which the caller cannot affirm respiratory arrest.

ABSTRACT

Objective: The goal of this study is to evaluate the association between the conditions of the victims at the time of the 119 calls and the patient’s prognoses.

Received: 
18 Aug, 2016
Accepted: 
13 Feb, 2017
PDF Attachment: 
PDF icon iwamura_et_al-relationship_between_symptoms_and_prognoses_at_the_time_of_emergency_calls.pdf
Journal Sections: 
Original Articles
Keywords: 
Emergency medical dispatch
out-of-hospital cardiac arrest
instructions for CPR
Journal Authors: 
T Iwamura
S Inoue
KC Yamada
H Koami
T Miike
M Yahata
H Imahase
Y Sakamoto
e-Published: 02 Mar, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Coconut Water Improves Reproductive Functions in Offspring of High Fat Diet Fed Rats

DOI: 
10.7727/wimj.2016.474
Synopsis: 
Assessed in this study, were the hypolipidemic actions of coconut water in the prevention of maternal high fat diet-induced reproductive dysfunction in rats' offspring. The results suggest that coconut water can effectively alleviate the reduction in fertility indices of such offspring.

ABSTRACT

Objective: Maternal high fat diet adversely affects fertility of offspring. Coconut (Cocos nucifera L.) water has hypolipidemic actions in the presence of high fat diets. This study was carried out to determine if coconut water (CW) can protect the reproductive functions of offspring against the effects of maternal high fat diet (HFD).

Received: 
06 Sep, 2016
Accepted: 
13 Feb, 2017
PDF Attachment: 
PDF icon kunle-alabi_et_al-coconut_water_improves_offsprings_reproductive_functions.pdf
Journal Sections: 
Original Articles
Keywords: 
Fertility
Coconut Water
Offspring
maternal high fat diet
Journal Authors: 
OT Kunle-Alabi
OO Akindele
Y Raji
e-Published: 28 Feb, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Application of Stepwise Small Dural Window and External Intraventricular Drainage for Craniectomy in Patients with Severe Brain Injury

DOI: 
10.7727/wimj.2016.217
Synopsis: 
The present study was designed to discuss the practicability and value of stepwise small dural window and Paine's point puncture mediated external intraventricular drainage (EID) for craniectomy in patients with severe brain injury compared with standard trauma craniectomy．

ABSTRACT

Objective: The present study was designed to discuss the practicability and value of stepwise small dural window and Paine's point puncture mediated external intraventricular drainage (EID) for craniectomy in patients with severe brain injury compared with standard trauma craniectomy．

Received: 
10 May, 2016
Accepted: 
13 Feb, 2017
PDF Attachment: 
PDF icon ziejie_et_al-small_dural_window_for_craniectomy_2.pdf
Journal Sections: 
Original Articles
Keywords: 
Craniectomy
EID
improved stepwise small dural window
severe brain injury
Journal Authors: 
Z Zhijie
W Zhenzhong
Z Bo
C Liqun
e-Published: 28 Feb, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Prevalence of Mental Disorders in Martinique, French West Indies: A Community-based Epidemiological Study

Issue: 
Vol 67, Issue 4: 2018
DOI: 
10.7727/wimj.2016.216
Pages: 
317-22
Synopsis: 
In an epidemiological study done in Martinique in 2000, using the Mini International Neuropsychiatric Interview (MINI), we have found that mental disorders, in particular mood and anxiety disorders, were as frequents as in mainland France.

ABSTRACT

Received: 
10 May, 2016
Accepted: 
13 Feb, 2017
Published: 
31 Dec, 2018
PDF Attachment: 
PDF icon wimj-iss4-2018_317_322.pdf
Journal Sections: 
Original Articles
Keywords: 
epidemiology
health survey
Martinique
mental disorders
prevalence
Journal Authors: 
J Lacoste
S Merle
N Ballon
A Charles-Nicolas
G Ursulet
A Messiah
e-Published: 27 Feb, 2017

Rhubarb Extract's Inhibiting Effects on α-Glucosidase's Activities in the Small Intestines of Type 1 Diabetic Rats

DOI: 
10.7727/wimj.2016.247
Synopsis: 
This study researched rhubarb extract's inhibiting-effect on α-glucosidase's activity in small intestine of rats with Type 1 diabetes. The result showed Rhubarb can inhibit α-glucosidase's activity in the small intestine of Type 1 diabetic rats.

ABSTRACT

Received: 
07 Jun, 2016
Accepted: 
22 Aug, 2016
Journal Sections: 
Original Articles
Keywords: 
Acarbose
rhubarb extract
α-glucosidase
diabetic rats
Journal Authors: 
KJ Hou
C Chen
XH Wang
CJ Lin
BT Wu
D Zhu
QM Chen
L yang
JR Yan
e-Published: 10 Feb, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Pharmacological Evaluation of Tamarix aphylla for Anti-inflammatory, Anti-pyretic and Anti-nociceptive Activities in Standard Animal Models

DOI: 
10.7727/wimj.2016.346
Synopsis: 
The present study provides pharmacological base for the medicinal use of Tamarix aphylla as anti-inflammatory, anti-pyretic and antinociceptive herbal remidies in standard animal models such as carrageenan induced edema and xylene induced ear edema models for anti-inflammatory, brewer yeast induced pyrexia model for anti-pyretic activity, hot plate and acetic acid induced writhing models for anti-nociceptive properties.

ABSTRACT

Objectives: The objective of this study was to assess anti-inflammatory, anti-pyretic and anti-nociceptive activities of methanol extract of Tamarix Aphylla (TAME) in experimental animal models.

Received: 
07 Jul, 2016
Revised: 
09 Jan, 2017
Accepted: 
13 Jan, 2017
PDF Attachment: 
PDF icon iqbal_et_al-pharmacological_evaluation_of_tamarix_aphylla.pdf
Journal Sections: 
Original Articles
Keywords: 
anti-inflammatory
Analgesic
antipyretic
Tamarix aphylla
Journal Authors: 
A Iqbal
Siraj-ud-Din
I Khan
G AlI
Z Ur Rahman
F Rabi
M Saleem Khan
e-Published: 03 Feb, 2017

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Robust Watermarking Technique Used in Medical Volume Data

Issue: 
Vol 65, Issue 4: 2016 – Health Science
DOI: 
10.7727/wimj.2016.249
Synopsis: 
There is the risk of breach of confidentiality as far as medical data is concerned. A robust watermarking technique is proposed as suitable for medical volume data concerned with privacy protection, safety and management.

ABSTRACT

PDF Attachment: 
PDF icon han_et_al-robust_watermarking_technique.pdf
Journal Sections: 
Original Articles
Keywords: 
Chebyshev chaotic neural network
medical volume data
robust
watermarking
Journal Authors: 
BR Han
JB Li
L Zong
e-Published: 03 Feb, 2017

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

Observation of the Efficacy of Acupuncture in Patients with Hypertension

Issue: 
Vol 65, Issue 4: 2016 – Health Science
DOI: 
10.7727.2016.256
Synopsis: 
Acupuncture therapy could reduce blood pressure in patients with hypertension.

ABSTRACT

Objective: To investigate the efficacy of acupuncture in the treatment of hypertension in patients from April 2011 to May 2014.

Method: One hundred and six patients with hypertension were divided into two groups: 53 cases in the control group were on oral administration of nifedipine sustained-release (SR) tablets, and the 53 cases in the observation group were on oral nifedipine SR and acupuncture treatment.

Received: 
07 Jun, 2016
Accepted: 
22 Aug, 2016
PDF Attachment: 
PDF icon wu_et_al-acupuncture_therapy_and_hypertension_3.pdf
Journal Sections: 
Original Articles
Keywords: 
blood pressure
Hypertension
Acupuncture
Journal Authors: 
QT Wu
JW Gan
J Zhang
e-Published: 03 Feb, 2017

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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