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In Vitro Anti-Proliferation/Cytotoxic Activity of Epingaione and its Derivatives on the Human SHSY5Y Neuroblastoma and TE-671 Sarcoma cells

Epingaione (4-Methyl-1-(5-methyl-2,3,4,5-tetrahydro-[2,3’]bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24% and 50.83% anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 μg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested.

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e-Published: 01 Jul, 2013

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This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

Evaluation and Management of Hypertension in the Elderly

Issue: 
DOI: 
10.7727/wimj.2012.063
Pages: 
907–11
Synopsis: 
Screening for elevated blood pressure in the elderly is recommended, since the prevalence of hypertension increases with age, and can reduce the incidence of morbidity and mortality. A careful and individualized approach is needed when treating hypertension in the elderly, taking into account the presence of co-morbid diseases, drug interaction, side effects, lifestyle and functional state.

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e-Published: 24 Jun, 2013

Human Immunodeficiency Virus Type-1 (HIV-1) Subtypes in Jamaica

Issue: 
Pages: 
279–82
Synopsis: 
The majority of strains of HIV-1 isolated from HIV-1 infected individuals in Jamaica were found to be HIV- 1 subtype B. The less frequently found HIV-1 subtypes were C, D and E and some strains were untypable by the methods used.

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e-Published: 06 Jun, 2013

Evaluation and Management of Hypertension in the Elderly

DOI: 
10.7727/wimj.2012.063

ABSTRACT

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e-Published: 21 Feb, 2013

Pre-published Manuscript

This manuscript has been assigned to a volume and issue but has not yet been published. It is either being edited, typeset or is in the proof stage of publication.
In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.

The Prevalence and Significance of Oestrogen Receptor (ER) Positivity in Breast Cancer at the University Hospital of the West Indies, Jamaica

Issue: 
DOI: 
10.7727/wimj.2012.121
Pages: 
795–801
Synopsis: 
Oestrogen receptor (ER) status was positive in 125 (63%) and negative in 74 (37%) patients diagnosed with breast cancer. By comparing the cohorts of ER negative to ER positive patients, one can accurately identify which clinical variables bear clinical significance in this population and are affected by ER status, as well as impact patient outcome.

ABSTRACT

 Objective:  To identify the prevalence of oestrogen receptor (ER) positivity, and determine the relationship of ER status with patient and tumour characteristics, in patients with breast cancer.

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e-Published: 21 Jan, 2013

Mental Health Issue

Issue: 
Pages: 
473–4

Introduction

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e-Published: 28 Aug, 2012

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