Original Articles

Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension

Issue:

Vol 69, Issue 9: 2023

DOI:

10.7727/wimj.2015.222

Pages:

638-44

Synopsis:

We evaluated the effect of rapamycin on pulmonary arterial hypertension. Rapamycin provided improvements in exercise capacity, right ventricular systolic pressure and hypertrophy, but those were not significant. There were significant recoveries in the pulmonary artery muscular layer thickness and in the median life span of rats.

ABSTRACT

Background: Pulmonary arterial hypertension (PAH) is a serious disease characterized by the progressive elevation of the pulmonary arterial resistance, leading to the right ventricular failure and death. Objective: To evaluate the effect of rapamycin (RAPA), a potent cell-cycle inhibitor, on exercise capacity, right ventricular hypertrophy and pulmonary vascular remodelling on rats.

Received:

04 May, 2015

Accepted:

18 May, 2015

Published:

25 Jan, 2023

PDF Attachment:

wimj-iss9-2023_638_644.pdf

Journal Sections:

Original Articles

Keywords:

Life expectancy

Pulmonary hypertension

Journal Authors:

e-Published: 13 Aug, 2015

Read more about Rapamycin Improves Vascular Remodelling in a Controlled Rat Model of Monocrotaline-Induced Pulmonary Hypertension

Sperm Quality as a Prognosticator in Intrauterine Insemination-treated Sub-Fertile Saudi Patients

DOI:

10.7727/wimj.2015.245

Synopsis:

The study was designed to determine the most effective sperm parameter(s) that would help in prescribing intrauterine insemination (IUI) for infertility treatment, within a Saudi infertility patient sample for the first time. We concluded that the post-sperm preparation total motile sperms count (TMSC) is the main determining component among sperm quality parameters, and that the TMSC of at least ten million men are the recommended numbers for the IUI success.

ABSTRACT

Background: Intrauterine Insemination (IUI) stays as the most feasible infertility treatment, yet its success indications need further refinement.

Objective: This study aims to determine the most effective sperm parameters that help in prescribing IUI for infertility treatment within a Saudi population sample.

Received:

19 May, 2015

Accepted:

10 Aug, 2015

PDF Attachment:

isa-sperm_quality_and_iui_success.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 11 Aug, 2015

Read more about Sperm Quality as a Prognosticator in Intrauterine Insemination-treated Sub-Fertile Saudi Patients

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Effect of Light Curing Mode and Type on Conversion of Resin Composites

Issue:

Vol 69, Issue 8: 2022

DOI:

10.7727/wimj.2015.031

Pages:

555-8

Synopsis:

In the study reported, the efficacy of polymerization for two curing units was determined by examining the degree of conversion for different composite materials. The degree of conversion values varied according to the type of resin (nanofilled-macrofilled-hybrid-microhybridormocer), brand and light polymerizing unit.

ABSTRACT

Objective: To determine the efficacy of polymerization for two different curing units by examining the degree of conversion (DC) of seven different composite materials.

Received:

26 Jan, 2015

Accepted:

25 Mar, 2015

Published:

20 Jul, 2022

PDF Attachment:

wimj-iss8-2022_555_558.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 11 Aug, 2015

Read more about Effect of Light Curing Mode and Type on Conversion of Resin Composites

Cigarette Smoking Increases Pregnancy-associated Plasma Protein-A in Men

Issue:

Vol 66, Issue 1: 2017

DOI:

10.7727/wimj.2014.371

Pages:

150–3

Synopsis:

Elevation of pregnancy-associated plasma protein-A (PAPP-A), is considered as an independent risk factor for acute coronary syndrome (ACS). We found significantly high PAPP-A level in the serum of male smokers and this may indicate a higher risk for ACS among these men.

ABSTRACT

Received:

03 Dec, 2014

Accepted:

07 Jan, 2015

Published:

08 Mar, 2017

PDF Attachment:

wimjiss12017_150_153.pdf

Journal Sections:

Original Articles

Keywords:

Smoking

Lung Cancer

Acute coronary syndrome

Pregnancy-associated Plasma Protein-A

Journal Authors:

e-Published: 30 Jul, 2015

Read more about Cigarette Smoking Increases Pregnancy-associated Plasma Protein-A in Men

Oral Signs Unraveling the Diagnosis of HIV

Issue:

Vol 66, Issue 2: 2017

DOI:

10.7727/wimj.2014.197

Pages:

214–9

Synopsis:

The study discusses the importance of awareness of oral manifestations of HIV, as it may reveal important information regarding the immune status of the individual, and, thus help in the identification of patients harbouring the HIV virus, as well as in predicting the decline in their immune status.

ABSTRACT

Received:

26 Aug, 2014

Revised:

25 Feb, 2015

Accepted:

02 Mar, 2015

Published:

22 Sep, 2017

PDF Attachment:

wimj-iss2-2017_214_219.pdf

Journal Sections:

Original Articles

Keywords:

B-cell lymphoma

HIV

oral hairy leukoplakia

Journal Authors:

e-Published: 24 Jul, 2015

Read more about Oral Signs Unraveling the Diagnosis of HIV

Use of Percutaneous Sonographically Guided Microwave Ablation Therapy to Treat Inoperable Malignant Liver Tumours

Issue:

Vol 64, Issue 2: March (2015)

DOI:

10.7727/wimj.2014.132

Pages:

76–80

Synopsis:

Microwave ablation (MWA) is a technique used to destroy tumours and soft tissues which are considered inoperable. It is also used to treat those patients who are ineligible for surgery. There is considerable efficacy of MWA guided by ultrasound in treating patients with inoperable tumours.

ABSTRACT

Aims: Microwave ablation (MWA) is a technique which is used to destroy tumours and soft tissues by using microwave energy to create coagulation and localized tissue necrosis. It is used to treat the tumours which are considered to be inoperable and used to treat those patients who are ineligible for surgery due to some factors. The main objective of this study was to evaluate the use of MWA in the treatment of liver cancer.

Received:

27 May, 2014

Accepted:

10 Jun, 2014

PDF Attachment:

wimjmar2015_76_80.pdf

Journal Sections:

Original Articles

Keywords:

treatment

hepatocellular carcinoma

Journal Authors:

e-Published: 23 Jul, 2015

Read more about Use of Percutaneous Sonographically Guided Microwave Ablation Therapy to Treat Inoperable Malignant Liver Tumours

Alcoholic Extract of Lotus Leaves Improves Lipid Profile in Rats with HIV Protease Inhibitor-induced Dyslipidaemia

Issue:

Vol 64, Issue 3: June (2015)

DOI:

10.7727/wimj.2014.373

Pages:

195–200

Synopsis:

Dyslipidaemia was induced in rats and was treated with alcoholic extracts of lotus leaves for four weeks. Total cholesterol and glycerides decreased but did not reach their normal levels.

ABSTRACT

Objective: To examine the effect of the alcoholic extract of lotus leaves (AELL) on antiretroviral treatment-induced dyslipidaemia in a rat model.

Received:

03 Dec, 2014

Accepted:

25 Mar, 2015

PDF Attachment:

wimjjun2015_195_200.pdf

Journal Sections:

Original Articles

Keywords:

Highly Active Antiretroviral Therapy (HAART)

Journal Authors:

e-Published: 21 Jul, 2015

Read more about Alcoholic Extract of Lotus Leaves Improves Lipid Profile in Rats with HIV Protease Inhibitor-induced Dyslipidaemia

Detection of HPV Infection in Non-cancer Oesophageal Lesions and Normal Tissue by Nested Polymerase Chain Reaction

Issue:

Vol 65, Issue 3: 2016

DOI:

10.7727/wimj.2014.322

Pages:

496-99

Synopsis:

Human papilloma virus (HPV) can be the aetiologic factor in the benign or malignant oesophageal epithelium. Nested PCR was performed for detection of HPV in non-cancer oesophageal lesions. A third (33.7%) of samples were infected with HPV DNA. This can lead to cell changes that over many years may develop into cancer.

ABSTRACT

Received:

18 Nov, 2014

Accepted:

05 Jan, 2015

PDF Attachment:

wimj_iss3_2016_496_499.pdf

Journal Sections:

Original Articles

Keywords:

HPV

human papilloma virus

Journal Authors:

e-Published: 21 Jul, 2015

Read more about Detection of HPV Infection in Non-cancer Oesophageal Lesions and Normal Tissue by Nested Polymerase Chain Reaction

Medical Causes of Death among the Elderly in a Tertiary Hospital, South East Nigeria

Issue:

Vol 66, Issue 1: 2017

DOI:

10.7727/wimj.2014.326

Pages:

50–5

Synopsis:

We reviewed the causes of death among the elderly aged 60 years and above. Cerebrovascular accident, chronic kidney disease, and diabetic complications were the most common causes of death among men, while cerebrovascular accident, heart failure from especially hypertensive heart disease and chronic kidney disease were the most common causes of death among women.

ABSTRACT

Background: There are few data on morbidity and mortality patterns among the elderly in Africa, especially in Sub-Saharan Africa (SSA). The aim of this study was to determine the causes of death among the elderly population in the internal medicine wards of a tertiary health institution in South East Nigeria.

Received:

19 Nov, 2014

Accepted:

06 Jan, 2015

Published:

08 Mar, 2017

PDF Attachment:

wimjiss12017_50_55_0.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 17 Jul, 2015

Read more about Medical Causes of Death among the Elderly in a Tertiary Hospital, South East Nigeria

Exploring Engineering Solutions in the Hope of Improving Dialysis Care

Issue:

Vol 66, Issue 2: 2017

DOI:

10.7727/wimj.2015.117

Pages:

244–9

Synopsis:

This study investigated aspects of dialysis care which are often neglected. It looked at patient comfort and aspects of treatment that patients would like to see improved which were amenable to an engineering solution.

ABSTRACT

Background: This study investigated aspects of dialysis care which are often neglected. It looked at patient comfort and aspects of treatment that patients would like to see improved which were amenable to an engineering solution.

Methods: The results were obtained from 12 patients at the Scarborough General Hospital’s Dialysis Center, located at 78 Corporate Drive, Scarborough, Ontario.

Received:

26 Feb, 2015

Accepted:

23 Mar, 2015

Published:

22 Sep, 2017

PDF Attachment:

wimj-iss2-2017_244_249.pdf

Journal Sections:

Original Articles

Keywords:

Dialysis