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Original Articles

Discrepancies between Clinical and Autopsy Diagnoses in the Emergency Department of the University Hospital of the West Indies

Issue: 
Vol 66, Issue 2: 2017
DOI: 
10.7727/wimj.2015.192
Pages: 
311–7
Synopsis: 
The discrepancy rate between the clinical and autopsy cause of death diagnoses was 36.8%. The high frequency of discrepant diagnoses among older age groups, combined with the diagnostic challenges in the Emergency Department related to time and patient co-morbidities, highlight the need to increase the autopsy rate.

ABSTRACT

Objectives: To determine the cause of death diagnoses and the discrepancy rate between clinical and autopsy diagnoses in the Emergency Department (ED) of the University Hospital of the West Indies (UHWI).

Received: 
20 Apr, 2015
Accepted: 
29 Apr, 2015
Published: 
22 Sep, 2017
PDF Attachment: 
PDF icon wimj-iss2-2017_311_317.pdf
Journal Sections: 
Original Articles
Keywords: 
Cause of death
Autopsy
Diagnostic Errors/ standards
Emergency service
Hospital/ standards
Journal Authors: 
TN Gibson
SE Shirley
EW Williams
A Rhudd
S French
R Hibbert
e-Published: 06 Nov, 2015

A Rapid and Sensitive LC-MS Method for the Estimation of Tolterodine Tartrate in Human Plasma

DOI: 
10.7727/wimj.2015.274
Synopsis: 
A selective and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been developed for the determination of tolterodine tartrate in human plasma. The validated LC–ESI–MS method has been used successfully to study tolterodine tartrate pharmacokinetic, bioavailability and bioequivalence in 12 healthy male volunteers.

ABSTRACT

Received: 
28 May, 2015
Accepted: 
24 Aug, 2015
Journal Sections: 
Original Articles
Keywords: 
Human plasma
LC-MS
pharmacokinetics
tolterodine tartrate
Journal Authors: 
H Danafar
M Hamidi
e-Published: 06 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Assesment of Paediatric Varicella Pneumonia

Issue: 
Vol 65, Issue 3: 2016
DOI: 
10.7727/wimj.2014.376
Pages: 
450-4
Synopsis: 
Varicella pneumonia is serious health problem in developing countries. The present study was evaluate the clinical presentation, diagnosis, treatment and respiratory complications of varicella zoster pneumonia in children.

ABSTRACT

Background: The objective of the study was to determine the clinical presentation, diagnosis, treatment, and respiratory complications of varicella zoster pneumonia (VZP) in children.

Received: 
04 Dec, 2014
Revised: 
17 Jun, 2015
Accepted: 
10 Aug, 2015
PDF Attachment: 
PDF icon wimj_iss3_2016_450_454.pdf
Journal Sections: 
Original Articles
Keywords: 
Acyclovir
Child
Pneumonia
varicella zoster
Journal Authors: 
F Aktar
R Tekin
MS Bektaş
M Köstü
S Aktar
A Güneş
Ü Uluca
V Sen
S Hattapoglu
e-Published: 06 Nov, 2015

Establishing a Telephone Medication Order Policy and Protocol for a Small Private Hospital in Jamaica

Issue: 
Vol 65, Issue 2: 2016
DOI: 
10.7727/wimj.2014.214
Pages: 
328-31
Synopsis: 
The absence or lack of adherence to a standard protocol in the administration of telephone medication orders places patients in jeopardy of experiencing medication errors and potential untoward health implications and healthcare organizations at risk for undesirable outcomes.

ABSTRACT

Objective: To institutionalize an evidence-based policy/protocol adapted from the Agency for Healthcare Research and Quality (AHRQ) national medication standards for managing telephone medication orders (TMO) and determine the impact of the policy/protocol on the number of telephone medication errors (TME) on two medical units of a small private hospital in Jamaica.

Received: 
28 Aug, 2014
Accepted: 
08 Sep, 2014
PDF Attachment: 
PDF icon wimj_iss2_2016_328-31.pdf
Journal Sections: 
Original Articles
Keywords: 
medication errors
medication guidelines
organizational change
telephone medication order
Journal Authors: 
M Grant-Coke
DL Powell
J Lyttle
H Hewitt
e-Published: 05 Nov, 2015

Assessing Islet Function Using two-hour Postprandial C Peptide in Type 2 Diabetes Mellitus

Issue: 
Vol 66, Issue 6: 2017
DOI: 
10.7727/wimj.2015.025
Pages: 
605–609
Synopsis: 
The present study aimed at exploring the role of two hour postprandial C peptide (2HPC-P) for assessing islet β-cell function in T2DM in order to guide treatment selection for patients with newly diagnosed T2DM.

Abstract

Objective: This study aims to investigate the role of 2-h postprandial C peptide (2HPC-P) for assessing islet β-cell function in Type 2 diabetes mellitus (T2DM).

Received: 
26 Jan, 2015
Accepted: 
30 Mar, 2015
Published: 
29 Dec, 2017
PDF Attachment: 
PDF icon wimj-iss6-2017_605_609.pdf
Journal Sections: 
Original Articles
Keywords: 
Type 2 diabetes mellitus
C peptide
Intensive therapy
Islet functions
Journal Authors: 
Z Tang
H Xi
X Zhu
T Yin
X Zhang
S Cui
B Shi
e-Published: 04 Nov, 2015

A Comparison of Serum Lead Status among Elderly Osteopaenic Patients, Elderly Osteoporotic Patients and Healthy Controls

Issue: 
Vol 67, Issue 3: 2018
DOI: 
10.7727/wimj.2015.103
Pages: 
248-53
Synopsis: 
It is proposed that in conditions where the bone turnover rate is high, mobilization of lead from bone to blood will occur. Mobilization of lead from bone to blood in elderly osteopaenic patients and elderly osteoporotic patients was similar to that in healthy controls.

ABSTRACT

Objective: It is proposed that in some conditions such as pregnancy and osteoporosis where the bone turnover rate is high, there is mobilization of various minerals including lead (Pb) from bone to blood. This study aimed to determine if there were any differences in serum Pb levels among elderly osteopaenic patients, elderly osteoporotic persons and healthy controls.

Received: 
24 Feb, 2015
Accepted: 
20 Mar, 2015
Published: 
31 Oct, 2018
PDF Attachment: 
PDF icon wimj-iss3-2018_248_253.pdf
Journal Sections: 
Original Articles
Keywords: 
lead
mobilization
osteopaenia
Osteoporosis
Journal Authors: 
H Moemeni
M Moallem
H Parsian
SR Hosseini
H Noreddini
A Mosapour
H Negahdar
M Alizadeh
ZS Kelagari
e-Published: 04 Nov, 2015

Clinical Observation of Foam Sclerotherapy Combined with Ligation of Great Saphenous Vein in the Treatment of Great Saphenous Varicose Veins

DOI: 
10.7727/wimj.2015.164
Synopsis: 
High ligation of the great sapheneous vein, combined with foam sclerotherapy, is a kind of new treatment technology which can shorten the operation time, reduce intraoperation bleeding, shorten the postoperative recovery, and reduce the operation expenditure.

ABSTRACT

Objetive: This study aims to compare the curative effect of ultrasound guided foam sclerotherapy in combination with ligation of great saphenous varicose vein with stripping of great saphenous vein in the treatment of great saphenous varicose veins.

Received: 
20 Mar, 2015
Accepted: 
20 Mar, 2015
PDF Attachment: 
PDF icon li20et20al-treatment20of20great20saphenous20varicose20veins1.pdf
Journal Sections: 
Original Articles
Keywords: 
foam sclerotherapy
great saphenous
ligation of varicose veins
stripping of varicose veins
Journal Authors: 
H Li
X Tong
X Qiu
e-Published: 04 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Investigation of the Anti-inflammatory and Analgesic Effects of the Aqueous Extract Obtained from the Bark of Guiacum Officinale (Lignum Vitae)

Issue: 
Vol 66, Issue 6: 2017
DOI: 
10.7727/wimj.2015.089
Pages: 
593–97
Synopsis: 
The bark of Guiacum Officinale (Lignum Vitae) is commonly used in folklore practice in Jamaica as a tea preparation to reduce inflammation and pain in knee joints. This study investigated and validated these claims and confirms no toxic effects within 24 hours at the doses used.

 ABSTRACT

Received: 
23 Feb, 2015
Accepted: 
26 Mar, 2015
Published: 
20 Dec, 2018
PDF Attachment: 
PDF icon wimj-iss6-2017_593_597.pdf
Journal Sections: 
Original Articles
Keywords: 
Analgesia
Extract
Guaiacum officinale
Inflammation
Lignum vitae
Journal Authors: 
K Williams
AS Jacob
SA Levy
e-Published: 04 Nov, 2015

Cytokine-induced Killer Cells Co-cultured with Dendritic Cell Benefit for the Treatment of MCF-7/ADR-Mammary Cancer with Multi-drug Resistance

DOI: 
10.7727/wimj.2015.474
Synopsis: 
After cytokine-induced killer cells (CIK) were co-cultured with dendritic cells (DC) loaded with multi-drug resistance tumor antigen, the higher antitumour immune response was evaluated to multi-drug resistance tumor expressed as the same tumour antigen. This provided the effective, clinical treatment for the multi-drug resistance tumour.

ABSTRACT

Cytokine-induced killer cells (CIK) are capable of lysing tumor cell and recognizing these cells in a non-MHC restricted fashion. After they were co-cultured with Dendritic cells (DC) loaded multidrug resistance tumor antigen, do they have the higher antitumor effect to the same multidrug resistance tumor?

Received: 
01 Sep, 2015
Accepted: 
11 Sep, 2015
PDF Attachment: 
PDF icon li20et20al-cik20cocultured20with20dc1.pdf
Journal Sections: 
Original Articles
Keywords: 
Cytokine-induced killer cells
dendritic cells
Multiple-drug resistance
MCF-7/ADR
Journal Authors: 
S Li
H Pang
e-Published: 03 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Simvastatin Modulates Parasitological Response to Sulfadoxine-pyrimethamine in Acute, Uncomplicated Malaria

DOI: 
10.7727/wimj.2015.416
Synopsis: 
The present study, which was aimed at evaluating the effects of simvastatin in modulating parasitological response to sulphadoxine-pyrimethamine, revealed that the significant improvement in parasitological response may be attributed to simvastatin use.

ABSTRACT

Background: Mutations in parasite enzymes and sub-optimal dosing associated with poor quality drug administration are considered major causes of parasitological resistance to sulfadoxine-pyrimethamine in the treatment of malaria.

Objectives: This study evaluated the effects of simvastatin in modulating parasitological response to sulfadoxine-pyrimethamine in the treatment of malaria.

Received: 
03 Aug, 2015
Accepted: 
11 Sep, 2015
PDF Attachment: 
PDF icon nwobodo20et20al-simvastatin20enhances20clinical20response1.pdf
Journal Sections: 
Original Articles
Keywords: 
Malaria
simvastatin
HMG-CoA reductase inhibitor
Parasite resistance
Parasitological response
Plasmodium falciparum
Journal Authors: 
NN Nwobodo
PO Okonkwo
e-Published: 03 Nov, 2015

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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