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Original Articles

Breast Cancer Receptor Profiles in Jamaica: A 6-year Analysis

Issue: 
DOI: 
10.7727/wimj.2016.067
Pages: 
13-7
Synopsis: 
This is the first report of the University of the West Indies (UWI) breast cancer immunohistochemistry (IHC) receptor database in which we present the results of tests performed during the six year period following its establishment in 2002, and investigate the associations between receptor profile and patient age, tumour grade and stage.

ABSTRACT

Objective: To determine the breast cancer immunohistochemistry (IHC) receptor status for tests performed at the University of the West Indies (UWI) from January 2002 to December 2007 and to investigate for an association between receptor profile and patient age, tumour grade and stage.

Accepted: 
20 Apr, 2016
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 27 Apr, 2016

Detection of OXA Carbapenemase Positive Acinetobacter spp., Jamaica

DOI: 
10.7727/wimj.2016.065
Synopsis: 
This article looks at the mechanism of carbapenem resistance and clonality of multidrug resistant Acinetobacter spp. at a hospital in Jamaica. PCR found that many of these isolates, some of which are clonally related, were carbapenemase producers.

ABSTRACT

Objective:  The global problem of resistance to carbapenem antibiotics, through the production of carbapenemases by clinically significant bacteria, continues to increase while options for antibiotic therapy remain limited. It is important to determine the mechanism of carbapenem resistance in the multidrug resistant (MDR) Acinetobacter spp.  isolated at a tertiary care hospital, Jamaica (TCHJ) because of the implications for therapy which is the goal of this study.

Accepted: 
20 Apr, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 27 Apr, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Factors Associated with High-grade Smear Positivity Levels in Pulmonary Tuberculosis

Issue: 
DOI: 
10.7727/wimj.2015.600
Pages: 
385-90
Synopsis: 
The present study aimed to investigate the relationship between smear results, the clinical features and the levels of radiological involvement of tuberculosis (TB). The high-grade level of smear acid-resistant bacilli positivity has been linked to increased infectiousness in pulmonary TB.

ABSTRACT

Objective: The high-grade level of smear acid-resistant bacilli (ARB) positivity has been linked to increased infectiousness in pulmonary tuberculosis (TB). The ability to predict infectiousness is important in the management of the disease. The present study aimed to investigate the relationship between smear results, the clinical features, and the levels of radiological involvement of TB.

Accepted: 
22 Apr, 2016
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e-Published: 22 Apr, 2016

Design of the Hospital Integrated Information Management System Based on Cloud Platform

Issue: 
DOI: 
10.7727/wimj.2016.057
Pages: 
521–6
Synopsis: 
The outdated information management style has become the bottleneck of hospital’s management and development. Hospital integrated information management system based on cloud platform software can optimize integration of hospital information resources and improve the level of standardized management. Meanwhile, the use of the cloud platform will reduce the hospital’s investment in hardware and software.

ABSTRACT

Accepted: 
08 Feb, 2016
PDF Attachment: 
Journal Sections: 
Journal Authors: 
e-Published: 18 Apr, 2016

Can the Medical-nursing Combined Care Promote the Accessibility of Health Services for the Elderly in Nursing Home? A Study Protocol of Analysis of the Effectiveness Regarding Health Service Utilization, Health Status and Satisfaction with Care

Issue: 
DOI: 
10.7727/wimj.2016.056
Pages: 
514–20
Synopsis: 
This article introduces the study protocol exploring the effectiveness of medical-nursing combined care in China regarding health service use, health status and service satisfaction in a population of the elderly living in nursing homes.

ABSTRACT

Accepted: 
08 Feb, 2016
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e-Published: 18 Apr, 2016

Modified Numerical Simulation Model of Blood Flow in Bend

Issue: 
DOI: 
10.7727/wimj.2016.054
Pages: 
495–8
Synopsis: 
The modified RNG k-ε model in bend can effectively improve the blood flow's numerical prediction accuracy affected by wall curvature effect, laying the foundation for further research on blood flow in bend.

ABSTRACT

The numerical simulation model of blood flow in bend is studied in this paper. The curvature modification is conducted for the blood flow model in bend to obtain the modified blood flow model in bend. The modified model is verified by U tube. By comparing the simulation results with the experimental results obtained by measuring the flow data in U tube, it was found that the modified blood flow model in bend can effectively improve the prediction accuracy of blood flow data affected by the curvature effect.

Accepted: 
08 Feb, 2016
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e-Published: 18 Apr, 2016

Testosterone Level in Testicular Cancer Patients after Chemotherapy

Issue: 
DOI: 
10.7727/wimj.2016.060
Pages: 
487–94
Synopsis: 
This study investigated the effects of chemotherapy on testosterone levels in testicular cancer patients. The hormone levels affected due to chemotherapy were differentiated from the effects of the tumour itself by comparing the hormone levels before the onset of chemotherapy to levels measured during and after completion of chemotherapy.

ABSTRACT

Background: The use of chemotherapy for the treatment of cancer began at the start of the 20th century in an attempt to narrow the universe of chemicals that affect the disease. Metastatic testicular cancer has always been sensitive to chemotherapy.  

Accepted: 
08 Feb, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 18 Apr, 2016

Combining Diffusion Tensor Imaging and Susceptibility Weighted Imaging on the Substantia Nigra of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-induced Rhesus Monkey Model of Parkinson’s Disease

Issue: 
DOI: 
10.7727/wimj.2016.051
Pages: 
480–6
Synopsis: 
Combining the use of diffusion tensor imaging and susceptibility weighted imaging can provide a sensitive method for differentiating between MPTP-induced rhesus monkey model of Parkinson’s disease and wild-type controls.

ABSTRACT

Objective: The aim of this study was to evaluate whether combining diffusion tensor magnetic resonance imaging (DTI) and susceptibility weighted imaging (SWI) techniques would provide a sensitive method for differentiating between 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced rhesus monkey model of Parkinson’s disease (PD) and wild-type controls.

Accepted: 
08 Feb, 2016
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Journal Sections: 
Journal Authors: 
e-Published: 18 Apr, 2016

The Effect and Mechanisms of Proliferative Inhibition of Crocin on Human Leukaemia Jurkat Cells

Issue: 
DOI: 
10.7727/wimj.2016.053
Pages: 
473–9
Synopsis: 
Crocin promoted Jurkat cell apoptosis and inhibited cell growth in a dose-time-dependent manner. These results suggest that crocin can be used as a suitable clinical agent for the treatment of T-lineage acute lymphoblastic leukaemia.

ABSTRACT

Accepted: 
08 Feb, 2016
PDF Attachment: 
Journal Sections: 
e-Published: 18 Apr, 2016

Protective Effects of Liquiritin on the Brain of Rats with Alzheimer’s Disease

Issue: 
DOI: 
10.7727/wimj.2016.058
Pages: 
468–72
Synopsis: 
Alzheimer’s disease (AD) is clinically manifested by progressive memory damage and cognitive dysfunction. In this study, a rat AD model with liquiritin (LQ) interference was established to observe the effects of LQ on the AD rats’ behavioural memory. The protective and antioxidant effects of LQ improved the rats’ learning and memory ability.

ABSTRACT

Background: Alzheimer’s disease (AD) is a sort of nerve degenerative disease with clinical manifestation of memory damage and cognitive dysfunction. Its typical pathological change is the abnormal deposition of amyloid-beta (Aβ).  

Method: In this study, a rat AD model with liquiritin (LQ) interference was established to observe the effects of LQ on the AD rats’ behavioural memory and primary hippocampus cells.  

Accepted: 
08 Feb, 2016
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Journal Sections: 
Journal Authors: 
e-Published: 18 Apr, 2016

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