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Original Articles

The Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein α Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients

Issue: 
Vol 69, Issue 7: 2022
DOI: 
10.7727/wimj.2015.446
Pages: 
494-8
Synopsis: 
In this article, we evaluated the prognostic value of FLT3-ITD and CCAAT-enhancer-binding protein α (CEBPA) mutations in acute lymphoblastic leukaemia. We did not detect any relationship between FLT3-ITD and CEBPA mutations as prognostic factors. However, FLT3-ITD mutation may affect the response to chemotherapy.

ABSTRACT

 

Background: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein α (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL.

Received: 
17 Aug, 2015
Accepted: 
08 Sep, 2015
Published: 
02 May, 2022
PDF Attachment: 
PDF icon wimj-iss7-2022_494_498.pdf
Journal Sections: 
Original Articles
Keywords: 
Acute lymphoblastic leukaemia
CCAAT enhancer binding protein α
FLT3
mutation
prognosis
Journal Authors: 
Ü Uluca
M Söker
MO Ayyıldız
M Yurt
V Sen
S Yel
A Güneş
S Coşkun
İ Tan
C Sahin
e-Published: 11 Feb, 2016

Insulin Value-added after Taking Glucose vs Blood Glucose Value-added after Sixty minutes Taking Glucose as a Good Index for Estimating βeta Cell Function by Non-specific Insulin Assay

Issue: 
Vol 66, Issue 2: 2017
DOI: 
10.7727/wimj.2014.333
Pages: 
208–13
Synopsis: 
Serum true insulin (TI), immunoreactive insulin (IRI), and glucose level in fasting and during an OGTT were measured in NGT，IGT and DM. We calculated ΔI60/ΔG60, HOMA-B and MBCI (Modified Beta Cell function Index) to estimate Beta cell function.

ABSTRACT

Objective: To determine the clinical significance of measuring serum true insulin (TI) in overweight and the non-obese with varying degrees of glucose tolerance, we estimated βeta cell (β- cell) function by calculating indices.

Received: 
21 Nov, 2014
Revised: 
01 Dec, 2014
Accepted: 
08 Feb, 2016
Published: 
22 Sep, 2017
PDF Attachment: 
PDF icon wimj-iss2-2017_208_213.pdf
Journal Sections: 
Original Articles
Keywords: 
βeta cell function
glucose tolerance test
true insulin
Journal Authors: 
P Yu
Q Li
F Liu
Y Sun
J Zhang
e-Published: 11 Feb, 2016

Therapeutic Effects of Tanshinone IIA towards Early Renal Damage in Patients with Type 2 Diabetes

DOI: 
10.7727/wimj.2015.376
Synopsis: 
There is a significant improvement in microalbuminuria, serum β2-croglobulin, urine B2-microglobulin and serum cystatin C by Tanshinone IIA in the management of early renal damage in patients with type 2 diabetes. Hence, Tanshinone 11A might alleviate early renal damage from diabetic nephropathy.

ABSTRACT

Aims: The present study aims to explore the role of Tanshinone IIA administration on the protective effect of early renal damage in patients with type 2 diabetes.

Received: 
06 Jul, 2015
Accepted: 
10 Sep, 2015
PDF Attachment: 
PDF icon han_et_al-tanshinone_iia_ameliorates_early_diabetic_nephropathy.pdf
Journal Sections: 
Original Articles
Keywords: 
renal damage
Type 2 diabetes
Tanshinone IIA
Journal Authors: 
F Han
Li Sheng
Q Jian
Q Weng
e-Published: 11 Feb, 2016

Disclaimer

Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.

The Prognostic Importance of Immunohistochemical Biomarkers in Diffuse Large B-Cell Lymphoma

Issue: 
Vol 69, Issue 1: 2021
DOI: 
10.7727/wimj.2015.550
Pages: 
38-43
Synopsis: 
Patients with diffuse large B cell lymphoma (DLBCL) were sub-classified by immunohistochemical method to evaluate the effects of subgroups on prognosis. The lymph node biopsy specimens of 40 patients with DLBCL were stained with monoclonal antibody immunstains of CD10, Bcl-6 and MUM1. Finally, MUM1 was found negatively correlated with overall survival and event-free survival.

ABSTRACT

Objective: Molecular methods have practical difficulties in identifying sub-groups of diffuse large B-cell lymphoma (DLBCL) in routine clinical practice. The goal of this study was to subclassify DLBCL patients into sub-groups by immunohistochemical method and to evaluate the effects of sub-groups on prognosis.

Received: 
05 Nov, 2015
Accepted: 
16 Nov, 2015
Published: 
30 Apr, 2021
PDF Attachment: 
PDF icon wimj-iss1-2021_38_43.pdf
Journal Sections: 
Original Articles
Keywords: 
Diffuse large B-cell lymphoma
immunohistochemistry methods
prognosis
Journal Authors: 
S Korkmaz
M Sencan
E Yildiz
H Terzi
R Egilmez
e-Published: 09 Feb, 2016

Thyroid Papillary Carcinoma in Paediatric and Adolescent Patients: Evaluation of Surgical Treatment in a Single Centre

Issue: 
Vol 69, Issue 5: 2021
DOI: 
10.7727/wimj.2015.413
Pages: 
273-6
Synopsis: 
In this paper, we present the clinical characteristics of thyroid papillary carcinoma determined in children and adolescents in our clinic, the surgical techniques applied, and the clinical results evaluated in light of the relevant literature.

ABSTRACT

Received: 
03 Aug, 2015
Accepted: 
16 Nov, 2015
Published: 
10 Nov, 2021
PDF Attachment: 
PDF icon wimj-iss5-2021_273_276.pdf
Journal Sections: 
Original Articles
Keywords: 
Adolescent
Carcinoma
papillary
thyroid.
Journal Authors: 
KÇ Özçelik
İ Zihni
O Karaköse
H Pülat
S Turanli
e-Published: 09 Feb, 2016

The Relationship between Somatotype and Dietary Intake of 6 to 13 Year-old, Rural South African Children: Ellisras Longitudinal Study

DOI: 
10.7727/wimj.2015.443
Synopsis: 
The relationship between dietary intake and somatotype attracts interest to many scientists. In the Ellisras rural children of South Africa, energy and total protein intake were significantly related to endomorphy. The risk of obesity among girls was eminent in the sample.

ABSTRACT

 Objectives:  Development of obesity related to dietary intake was linked to four stages of human growth. The aim of this study was to investigate the relationship between somatotype and dietary intake of Ellisras rural children aged 6 to 13 years.

Received: 
17 Aug, 2015
Accepted: 
02 Nov, 2015
PDF Attachment: 
PDF icon monyeki_et_al-_somatotype_and_dietary_intake_in_rural_south_african_children.pdf
Journal Sections: 
Original Articles
Keywords: 
diet
rural South African children
somatotype
under nutrition
Journal Authors: 
KD Monyeki
NE Ramoshaba
HCG Kemper
e-Published: 08 Feb, 2016

Disclaimer

Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.

The Effect of Continuous Positive Airway Pressure on Basal Metabolism Rate in Patients with Severe Obstructive Sleep Apnoea Syndrome

Issue: 
Vol 69, Issue 1: 2021
DOI: 
10.7727/wimj.2015.489
Pages: 
9-14
Synopsis: 
Basal metabolism rate is defined as the energy consumption required for maintaining body functions and metabolic activities. Previous studies have shown significantly higher energy consumption in patients with obstructive sleep apnoea syndrome (OSAS) compared to healthy subjects. The aim of this study was to evaluate the effects of short-term continuous positive airway pressure treatment on the basal metabolism rate in patients with severe OSAS.

ABSTRACT

Objective: To assess the effect of the continuous positive airway pressure (CPAP) treatment on basal metabolism rate (BMR) in patients with severe obstructive sleep apnoea syndrome (OSAS).

Received: 
07 Sep, 2016
Accepted: 
02 Nov, 2016
Published: 
30 Apr, 2021
PDF Attachment: 
PDF icon wimj-iss1-2021_9_14.pdf
Journal Sections: 
Original Articles
Keywords: 
Carbon dioxide output (VCO2)
continuous positive airway pressure treatment
obstructive sleep apnoea syndrome
oxygen consumption (VO2)
Journal Authors: 
T Onyilmaz
S Argun Baris
H Boyaci
I Basyigit
G Dogru
F Yildiz
e-Published: 08 Feb, 2016

Propolis and Caffeic Acid Phenethyl Ester Attenuates Nitrosative Stress in Lens Tissue in Radiation-induced Cataracts in Rats

Issue: 
Vol 69, Issue 5: 2021
DOI: 
10.7727/wimj.2015.445
Pages: 
362-7
Synopsis: 
The aim of this study was to investigate whether propolis and caffeic acid phenethyl ester (CAPE) prevent radiation-induced cataractogenesis. The results obtained in the study suggest that propolis and CAPE have free radical, scavenging activities in the irradiation-induced cataractogenesis.

 ABSTRACT

Objective: Eye morbidity is widely observed in patients receiving total body irradiation prior to bone marrow transplantation or radiotherapy for ocular or head and neck cancers. Cataract blindness is the major cause of preventable blindness worldwide, especially in the developing countries. The aim of this study was to investigate whether propolis and caffeic acid phenethyl ester (CAPE) prevent radiation-induced cataractogenesis.

Received: 
17 Aug, 2015
Accepted: 
08 Sep, 2015
Published: 
12 Nov, 2021
PDF Attachment: 
PDF icon wimj-iss5-2021_362_367.pdf
Journal Sections: 
Original Articles
Keywords: 
Caffeic acid phenethyl ester
Cataract
irradiation
nitrosative stress
propolis.
Journal Authors: 
S Taysi
S Okumus
E Saricicek
M Akyuz
V Saricicek
A Tascan
S Kenan
M Tarakcioglu
e-Published: 04 Feb, 2016

Personal and Behavioural Characteristics of Seat Belt Non-users in Slovenia

DOI: 
10.7727/wimj.2015.453
Synopsis: 
The results of our study showed that the important risk factors for seat belt non-users in the adult population in Slovenia are the social/demographic characteristics of gender, age, and education level.

ABSTRACT

 

Objective: In turn, personal and behavioural characteristics found in drivers who use seat-belts affect general traffic safety. The objective of our study was to determine the risk factors that affect seat-belt use across the observed behaviour-related groups of adult citizens of Slovenia.

Received: 
17 Aug, 2015
Accepted: 
08 Feb, 2015
PDF Attachment: 
PDF icon bilban_personal_and_behavioural_characteristics.pdf
Journal Sections: 
Original Articles
Keywords: 
Behaviour-related groups
risk factors
seat belt
traffic safety
Journal Authors: 
M Bilban
e-Published: 04 Feb, 2016

Disclaimer

Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.

A Wolf in Sheep's Clothing

DOI: 
10.7727/wimj.2015.442
Synopsis: 
We report a case of a woman admitted to our department with acute abdominal pain and fever. The surgical and histological investigation, revealed a rare coexistence that has never been mentioned in the published medical literature.

ABSTRACT

Aim: Adenocarcinoma is one of the most common malignant tumours of the small intestine complicating Crohn disease. However, the coexistence of both neoplasms with diverticulosis of small bowel in young age makes this coincidence rare and clinical diagnosis very difficult.

Received: 
17 Aug, 2015
Accepted: 
08 Sep, 2015
PDF Attachment: 
PDF icon spartalis_et_al-small_bowel_complications.pdf
Journal Sections: 
Original Articles
Keywords: 
Crohn’s disease
ileal diverticulosis
small bowel adenocarcinoma
Journal Authors: 
E Spartalis
D Moris
P Tsaparas
E-A Trigka
S Sakellariou
P Korkolopoulou
D Dimitroulis
D Mantas
e-Published: 04 Feb, 2016

Disclaimer

Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.

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West Indian Medical Journal

Faculty of Medical Sciences,
The University of the West Indies,
Mona, Kingston 7
Tel: (876) 927-1214
Fax: (876) 927-1846
wimj@uwimona.edu.jm
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