Original Articles

Is Imatinib Protective Against to Osteoporosis? - A Comparative Study in Terms of Bone Densitometry on Chronic Myeloid Leukaemia Patients and Healthy Volunteers

DOI:

10.7727/wimj.2015.447

Synopsis:

Previous studies have shown that imatinib affects bone metabolism in chronic myeloid leukemia (CML) patients. We aimed in this study to investigate whether the inhibition of tyrosine kinase is a new potential target against osteoporosis which is an important issue for public health.

ABSTRACTS

Received:

17 Aug, 2015

Accepted:

08 Sep, 2015

PDF Attachment:

gorgel_et_al-_is_imatinib_protective_against_to_osteoporosis.docx_.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 12 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Role of FLT3-ITD and CEBPA Mutations on the Prognosis of Acute Lymphoblastic Leukaemia in Turkish patients

DOI:

10.7727/wimj.2015.446

Synopsis:

In this article, we evaluated the prognostic value of FLT3-ITD and CEBPA mutations in ALL. We did not detect any relationship between FLT3-ITD and CEBPA mutations as prognostic factors. However, FLT3-ITD mutation may affect the response to chemotherapy.

ABSTRACT

Received:

17 Aug, 2015

Accepted:

08 Sep, 2015

PDF Attachment:

ulaca_et_al-_the_role_of_flt3-itd_and_cebpa_mutations.pdf

Journal Sections:

Original Articles

Keywords:

mutation

prognosis

Acute lymphoblastic leukaemia

Journal Authors:

e-Published: 11 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein α Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients

Issue:

Vol 69, Issue 7: 2022

DOI:

10.7727/wimj.2015.446

Pages:

494-8

Synopsis:

In this article, we evaluated the prognostic value of FLT3-ITD and CCAAT-enhancer-binding protein α (CEBPA) mutations in acute lymphoblastic leukaemia. We did not detect any relationship between FLT3-ITD and CEBPA mutations as prognostic factors. However, FLT3-ITD mutation may affect the response to chemotherapy.

ABSTRACT

Background: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein α (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL.

Received:

17 Aug, 2015

Accepted:

08 Sep, 2015

Published:

02 May, 2022

PDF Attachment:

wimj-iss7-2022_494_498.pdf

Journal Sections:

Original Articles

Keywords:

Acute lymphoblastic leukaemia

CCAAT enhancer binding protein α

Journal Authors:

e-Published: 11 Feb, 2016

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Insulin Value-added after Taking Glucose vs Blood Glucose Value-added after Sixty minutes Taking Glucose as a Good Index for Estimating βeta Cell Function by Non-specific Insulin Assay

Issue:

Vol 66, Issue 2: 2017

DOI:

10.7727/wimj.2014.333

Pages:

208–13

Synopsis:

Serum true insulin (TI), immunoreactive insulin (IRI), and glucose level in fasting and during an OGTT were measured in NGT，IGT and DM. We calculated ΔI60/ΔG60, HOMA-B and MBCI (Modified Beta Cell function Index) to estimate Beta cell function.

ABSTRACT

Objective: To determine the clinical significance of measuring serum true insulin (TI) in overweight and the non-obese with varying degrees of glucose tolerance, we estimated βeta cell (β- cell) function by calculating indices.

Received:

21 Nov, 2014

Revised:

01 Dec, 2014

Accepted:

08 Feb, 2016

Published:

22 Sep, 2017

PDF Attachment:

wimj-iss2-2017_208_213.pdf

Journal Sections:

Original Articles

Keywords:

βeta cell function

glucose tolerance test

Journal Authors:

e-Published: 11 Feb, 2016

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Therapeutic Effects of Tanshinone IIA towards Early Renal Damage in Patients with Type 2 Diabetes

DOI:

10.7727/wimj.2015.376

Synopsis:

There is a significant improvement in microalbuminuria, serum β2-croglobulin, urine B2-microglobulin and serum cystatin C by Tanshinone IIA in the management of early renal damage in patients with type 2 diabetes. Hence, Tanshinone 11A might alleviate early renal damage from diabetic nephropathy.

ABSTRACT

Aims: The present study aims to explore the role of Tanshinone IIA administration on the protective effect of early renal damage in patients with type 2 diabetes.

Received:

06 Jul, 2015

Accepted:

10 Sep, 2015

PDF Attachment:

han_et_al-tanshinone_iia_ameliorates_early_diabetic_nephropathy.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 11 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Prognostic Importance of Immunohistochemical Biomarkers in Diffuse Large B-Cell Lymphoma

Issue:

Vol 69, Issue 1: 2021

DOI:

10.7727/wimj.2015.550

Pages:

38-43

Synopsis:

Patients with diffuse large B cell lymphoma (DLBCL) were sub-classified by immunohistochemical method to evaluate the effects of subgroups on prognosis. The lymph node biopsy specimens of 40 patients with DLBCL were stained with monoclonal antibody immunstains of CD10, Bcl-6 and MUM1. Finally, MUM1 was found negatively correlated with overall survival and event-free survival.

ABSTRACT

Objective: Molecular methods have practical difficulties in identifying sub-groups of diffuse large B-cell lymphoma (DLBCL) in routine clinical practice. The goal of this study was to subclassify DLBCL patients into sub-groups by immunohistochemical method and to evaluate the effects of sub-groups on prognosis.

Received:

05 Nov, 2015

Accepted:

16 Nov, 2015

Published:

30 Apr, 2021

PDF Attachment:

wimj-iss1-2021_38_43.pdf

Journal Sections:

Original Articles

Keywords:

Diffuse large B-cell lymphoma

immunohistochemistry methods

Journal Authors:

e-Published: 09 Feb, 2016

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Thyroid Papillary Carcinoma in Paediatric and Adolescent Patients: Evaluation of Surgical Treatment in a Single Centre

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.413

Pages:

273-6

Synopsis:

In this paper, we present the clinical characteristics of thyroid papillary carcinoma determined in children and adolescents in our clinic, the surgical techniques applied, and the clinical results evaluated in light of the relevant literature.

ABSTRACT

Received:

03 Aug, 2015

Accepted:

16 Nov, 2015

Published:

10 Nov, 2021

PDF Attachment:

wimj-iss5-2021_273_276.pdf

Journal Sections:

Keywords:

Journal Authors:

e-Published: 09 Feb, 2016

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The Relationship between Somatotype and Dietary Intake of 6 to 13 Year-old, Rural South African Children: Ellisras Longitudinal Study

DOI:

10.7727/wimj.2015.443

Synopsis:

The relationship between dietary intake and somatotype attracts interest to many scientists. In the Ellisras rural children of South Africa, energy and total protein intake were significantly related to endomorphy. The risk of obesity among girls was eminent in the sample.

ABSTRACT

Objectives: Development of obesity related to dietary intake was linked to four stages of human growth. The aim of this study was to investigate the relationship between somatotype and dietary intake of Ellisras rural children aged 6 to 13 years.

Received:

17 Aug, 2015

Accepted:

02 Nov, 2015

PDF Attachment:

monyeki_et_al-_somatotype_and_dietary_intake_in_rural_south_african_children.pdf

Journal Sections:

Original Articles

Keywords:

diet

rural South African children

Journal Authors:

e-Published: 08 Feb, 2016

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Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

The Effect of Continuous Positive Airway Pressure on Basal Metabolism Rate in Patients with Severe Obstructive Sleep Apnoea Syndrome

Issue:

Vol 69, Issue 1: 2021

DOI:

10.7727/wimj.2015.489

Pages:

9-14

Synopsis:

Basal metabolism rate is defined as the energy consumption required for maintaining body functions and metabolic activities. Previous studies have shown significantly higher energy consumption in patients with obstructive sleep apnoea syndrome (OSAS) compared to healthy subjects. The aim of this study was to evaluate the effects of short-term continuous positive airway pressure treatment on the basal metabolism rate in patients with severe OSAS.

ABSTRACT

Objective: To assess the effect of the continuous positive airway pressure (CPAP) treatment on basal metabolism rate (BMR) in patients with severe obstructive sleep apnoea syndrome (OSAS).

Received:

07 Sep, 2016

Accepted:

02 Nov, 2016

Published:

30 Apr, 2021

PDF Attachment:

wimj-iss1-2021_9_14.pdf

Journal Sections:

Original Articles

Keywords:

Carbon dioxide output (VCO2)

continuous positive airway pressure treatment

obstructive sleep apnoea syndrome

oxygen consumption (VO2)

Journal Authors:

e-Published: 08 Feb, 2016

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Propolis and Caffeic Acid Phenethyl Ester Attenuates Nitrosative Stress in Lens Tissue in Radiation-induced Cataracts in Rats

Issue:

Vol 69, Issue 5: 2021

DOI:

10.7727/wimj.2015.445

Pages:

362-7

Synopsis:

The aim of this study was to investigate whether propolis and caffeic acid phenethyl ester (CAPE) prevent radiation-induced cataractogenesis. The results obtained in the study suggest that propolis and CAPE have free radical, scavenging activities in the irradiation-induced cataractogenesis.

ABSTRACT

Objective: Eye morbidity is widely observed in patients receiving total body irradiation prior to bone marrow transplantation or radiotherapy for ocular or head and neck cancers. Cataract blindness is the major cause of preventable blindness worldwide, especially in the developing countries. The aim of this study was to investigate whether propolis and caffeic acid phenethyl ester (CAPE) prevent radiation-induced cataractogenesis.

Received:

17 Aug, 2015

Accepted:

08 Sep, 2015

Published:

12 Nov, 2021

PDF Attachment:

wimj-iss5-2021_362_367.pdf

Journal Sections:

Original Articles

Keywords:

Caffeic acid phenethyl ester